Report
研究実績

香川大学救命救急センターでは、重症救急患者における病態生理の解明を目標とした各種研究を行っています。 特に、神経集中治療、頭部外傷、低体温療法などに関する研究を進めています。 既に臨床応用されている特殊な測定・評価手技として、急性期疾患に対するPET(陽電子断層撮像)や各種脳波モニタリング、頭蓋内圧、rSO2などのモニタリングなどがあります。

原著論文

Association Between Converting Asystole from Initial Shockable ECG Rhythm Before Extracorporeal Cardiopulmonary Resuscitation and Outcome. Keisuke Maeda, Akihiko Inoue, Yasuhiro Kuroda, Fumiya Inoue, Masafumi Suga, Shinichi Ijuin, Soichiro Kai, Tokito Koga, Nobuaki Igarashi, Shigenari Matsuyama, Tetsunori Kawase, Satoshi Ishihara, Hiroshi Naitou, and Shinichi Nakayama SHOCK 2021;56:5:701-708, : January 20, 2021 doi: 10.1097/SHK.0000000000001727

Association between physical restraint requirement and unfavorable neurologic outcomes in subarachnoid hemorrhage Akiyama K, Inoue A, Hifumi T, Nakamura K, Taira T, Nakagawa S, Jinno K, Manabe A, Kinugasa S, Matsumura H, Shishido H, Yokoyama S, Okazaki T, Hamaya H, Takano K, Kiridume K, Shinohara N, Kawakita K, Kuroda Y. J Intensive Care 2021 Mar 12;9(1):24. doi: 10.1186/s40560-021-00541-z. 33712088

Malocclusion of Molar Teeth Is Associated with Activities of Daily Living Loss and Delirium in Elderly Critically Ill Older Patients Yoshihisa Fujinami, Toru Hifumi, Yuko Ono, Masafumi Saito, Tomoya Okazaki, Natsuyo Shinohara, Kyoko Akiyama, Misa Kunikata, Shigeaki Inoue, Joji Kotani and Yasuhiro Kuroda Journal of Clinical Medicine 2021 10 2157 34067550

Neurological outcomes associated with prehospital advanced airway management in patients with out-of-hospital cardiac arrest due to foreign body airway obstruction Kanako Otomune, Toru Hifumi, Keisuke Jinno, Kentaro Nakamura, Tomoya Okazaki, Akihiko Inoue, Kenya Kawakita, Yasuhiro Kuroda Resuscitation plus 2021 May 27;7:100140. doi: 10.1016/j.resplu.2021.100140. eCollection 2021 Sep. 34223396

四宮理絵 岸上多栄子 山本潤美 粂橋美帆 國方美佐 黒田泰弘
香川県救急隊員の児童虐待対応に関する認識と経験についての調査研究
日臨救急医会誌(JJSEM)2021;24:346-53

Variability of extracorporeal cardiopulmonary resuscitation practice in patients with out-of-hospital cardiac arrest from the emergency department to intensive care unit in Japan. Toru Hifumi, Akihiko Inoue, Toru Takiguchi, Kazuhiro Watanabe, Takayuki Ogura, Tomoya Okazaki, Shinichi Ijuin, Ryosuke Zushi, Hideki Arimoto, Hiroaki Takada, Shinichirou Shiraishi, Yuko Egawa, Jun Kanda, Michitaka Nasu, Makoto Kobayashi, Masaaki Sakuraya, Hiromichi Naito, Shunichiro Nakao, Norio Otani, Ichiro Takeuchi, Naofumi Bunya, Takafumi Shimizu, Hirotaka Sawano, Wataru Takayama, Shigeki Kushimoto, Tomohisa Shoko, Makoto Aoki, Takayuki Otani, Yoshinori Matsuoka, Koichiro Homma, Kunihiko Maekawa, Yoshio Tahara, Reo Fukuda, Migaku Kikuchi, Takuo Nakagami, Yoshihiro Hagiwara, Nobuya Kitamura, Kazuhiro Sugiyama, Tetsuya Sakamoto, Yasuhiro Kuroda, SAVE-J II Study Group Acute Med Surg. 2021 May 1;8(1):e647. 33968411

Cerebral blood volume increment after resuscitation measured by near-infrared time-resolved spectroscopy can estimate degree of hypoxic-ischemic insult in newborn piglets Tsutomu Mitsuie, Shinji Nakamura, Yinmon Htun, Yasuhiro Nakao, Makoto Arioka, Kosuke Koyano, Aya Morimoto, Takayuki Wakabayashi, Yasuhiro Kuroda, Takashi Kusaka Scientific reports. 2021 Jun 23;11(1):13096. PMID: 34162942

The association between neuromuscular blockade use during target temperature management and neurological outcomes. Toru Hifumi, Akihiko Inoue, Hideki Arimoto, Naohiro Yonemoto, Yasuhiro Kuroda, Yoshio Tahara, Kenya Kawakita, Hiroyuki Yokoyama, Ken Nagao, Hiroshi Nonogi, the J-PULSE-Hypo Investigators . Am J Emerg Med. 2021;46:289-294. 33051089

Impact of Induced Therapeutic Hypothermia by Intravenous Infusion of Ice-Cold Fluids After Hospital Arrival in Comatose Survivors of Out-of-Hospital Cardiac Arrest With Initial Shockable Rhythm.
Masakazu Matsuzaki, MD; Naoya Matsumoto, MD; Ken Nagao, MD; Hirotaka Sawano, MD; Hiroyuki Yokoyama, MD; Yoshio Tahara, MD; Mamoru Hase, MD; Shinichi Shirai, MD; Hiroshi Hazui, MD; Hideki Arimoto, MD; Kazunori Kashiwase, MD; Shunji Kasaoka, MD; Tomokazu Motomura, MD; Yasuhiro Kuroda, MD; Yuji Yasuga, MD; Naohiro Yonemoto, PhD; Hiroshi Nonogi, MD for the J-PULSE-Hypo Investigators. Circ J. 2021. 85: 1842-1848 doi: 10.1253/circj.CJ-20-0793. 34261843

Cluster Randomized Trial of Duration of Cooling in Targeted Temperature Management After Resuscitation for Cardiac Arrest. Yoshio Tahara, Teruo Noguchi, Naohiro Yonemoto, Takahiro Nakashima, Satoshi Yasuda, Migaku Kikuchi, Katsutaka Hashiba, Hideki Arimoto, Kenji Nishioka, Nobuaki Kokubu, Takahiro Atsumi, Kazunori Kashiwase, Shunji Kasaoka, Yasuhiro Kuroda, Akiko Kada, Hiroyuki Yokoyama, Hiroshi Nonogi, for the J-PULSE-Hypo-DC Trial Study Group Circ Rep 2021; 3: 368-374. 34250277

Hypothermia for Patients Requiring Evacuation of Subdural Hematoma: A Multicenter Randomized Clinical Trial Georgene W Hergenroeder, Shoji Yokobori, Huimahn Alex Choi, Karl Schmitt, Michelle A Detry, Lisa H Schmitt, Anna McGlothlin, Ava M Puccio, Jonathan Jagid, Yasuhiro Kuroda, Yukihiko Nakamura, Eiichi Suehiro, Faiz Ahmad, Kert Viele, Elisabeth A Wilde, Stephen R McCauley, Ryan S Kitagawa, Nancy R Temkin, Shelly D Timmons, Michael N Diringer, Pramod K Dash, Ross Bullock, David O Okonkwo, Donald A Berry, Dong H Kim Neurocrit Care 2021 Sep 13. PMID: 34518968, DOI: 10.1007/s12028-021-01334-w

High early phase hemoglobin level is associated with favorable neurological outcome in patients with severe traumatic brain injury Toru Hifumi 1, Kentaro Nakamura 2, Yasuhiro Kuroda 2, Kenya Kawakita 2, Motoki Fujita 3, Susumu Yamashita 4, Kenji Dohi 5, Hitoshi Kobata 6, Eiichi Suehiro 3, Tsuyoshi Maekawa 7, Brain Hypothermia (B-HYPO) Study Group in Japan Am J Emerg Med. 2021 Jun;44:373-377. doi: 10.1016/j.ajem.2020.04.065. PMID: 32507479 DOI: 10.1016/j.ajem.2020.04.065

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